Trifluoroacetic acid → HCID 86693757, compound

HRID 1023501Notes

Reaction equation

HRID 1023501 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([C:12]([C:14]2[CH:42]=[CH:41][C:17]([O:18][C@@H:19]([C:22]3[O:26][N:25]=[C:24]([C:27]4[CH:39]=[CH:38][C:30]([C:31]([O:33]C(C)(C)C)=[O:32])=[C:29]([F:40])[CH:28]=4)[N:23]=3)[CH2:20][CH3:21])=[CH:16][CH:15]=2)=[O:13])[CH2:11][CH2:10][CH2:9]1>ClCCl>[CH:8]1([C:12]([C:14]2[CH:42]=[CH:41][C:17]([O:18][C@@H:19]([C:22]3[O:26][N:25]=[C:24]([C:27]4[CH:39]=[CH:38][C:30]([C:31]([OH:33])=[O:32])=[C:29]([F:40])[CH:28]=4)[N:23]=3)[CH2:20][CH3:21])=[CH:16][CH:15]=2)=[O:13])[CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86693758HCID 86693758, compound

Product 1

HCID 86693757HCID 86693757, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (5 mL) was added to a dichloromethane (5 mL) solution of the obtained tert-butyl 4-(5-{(1R)-1-[4-(cyclobutylcarbonyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluorobenzoate at room temperature, and the mixture was stirred for one hour. The solvent was distilled off under reduced pressure, and the resulting residue was solidified by using hexane:ethyl acetate (5:1, v/v). Thus, the title compound (531 mg, yield: 56%) was obtained.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-7578a57a9d284f20b7e0f16ad4c8a5de
Source dataset
uspto-grants-2014_05
Patent number
US08722711B2

Reaction notes

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