Ethanol → HCID 54736833, compound

HRID 1023675Notes

Reaction equation

HRID 1023675 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.C(O)C.[C:36]([NH2:40])([CH3:39])([CH3:38])[CH3:37]>O>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[C:36]([NH2:40])([CH3:39])([CH3:38])[CH3:37]

Participants

5

Reactant 3

HCID 702EthanolHCID 6385Tert-ButylamineHCID 54671008Raltegravir

Product 1

HCID 54736833HCID 54736833, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

A three necked round bottom flask (100 ml) was charged with Raltegravir free hydroxy (5 g), ethanol (45 ml) and water (5 ml) to obtain a mixture. The mixture was heated to 40° C. and tert-butylamine (1300 μl) was added dropwise. There was almost dissolution and heavy precipitation subsequently occurred. The precipitate was filtered under reduced pressure and dried overnight in a vacuum oven at 55° C. The resulting product was characterised by XRPD.

Workup

  1. customto obtain a mixture
  2. dissolutiondissolution and heavy precipitation
  3. filtrationThe precipitate was filtered under reduced pressure
  4. customdried overnight in a vacuum oven at 55° C

Sources & evidence

ORD record
ord-4332e516f35f4403ae138f45dd1ba1d2
Source dataset
uspto-grants-2014_05
Patent number
US08722722B2

Reaction notes

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