Tetrahydrofuran → HCID 66559253, compound

HRID 1023684Notes

Reaction equation

HRID 1023684 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[NH:33]([CH2:35][C@@H:36]([C@H:38]([C@@H:40]([C@@H:42]([CH2:44][OH:45])[OH:43])[OH:41])[OH:39])[OH:37])[CH3:34].C1COCC1>O>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[NH:33]([CH2:35][C@@H:36]([C@H:38]([C@@H:40]([C@@H:42]([CH2:44][OH:45])[OH:43])[OH:41])[OH:39])[OH:37])[CH3:34]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 8567N-Methyl-D-glucamineHCID 54671008Raltegravir

Product 1

HCID 66559253HCID 66559253, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A three necked round bottom flask (50 ml) was charged with Raltegravir free hydroxy (300 mg), Meglumine (132 mg), THF (15 mL) and water (7.5 mL) to obtain a mixture. The mixture was stirred at room temperature, yellow clear solution was obtained. The solution was evaporated and dried overnight in a vacuum oven at 60° C. The resulting product was characterised by XRPD.

Workup

  1. customto obtain a mixture
  2. customyellow clear solution was obtained
  3. customThe solution was evaporated
  4. customdried overnight in a vacuum oven at 60° C

Sources & evidence

ORD record
ord-235f8631e023415f8070b81fbe21dd83
Source dataset
uspto-grants-2014_05
Patent number
US08722722B2

Reaction notes

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