Hydrochloric Acid → HCID 51030104, compound

HRID 1023703Notes

Reaction equation

HRID 1023703 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[N:7]=[CH:6][N:5]([C:8]2[C:9]([CH3:19])=[CH:10][C:11]([CH3:18])=[C:12]([S:14](Cl)(=O)=O)[CH:13]=2)[N:4]=1.Cl>C(O)(=O)C.[Fe]>[S:14]([C:12]1[CH:13]=[C:8]([N:5]2[CH:6]=[N:7][C:3]([C:2]([F:21])([F:1])[F:20])=[N:4]2)[C:9]([CH3:19])=[CH:10][C:11]=1[CH3:18])[S:14][C:12]1[CH:13]=[C:8]([N:5]2[CH:6]=[N:7][C:3]([C:2]([F:21])([F:20])[F:1])=[N:4]2)[C:9]([CH3:19])=[CH:10][C:11]=1[CH3:18]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 42633764HCID 42633764, compound

Product 1

HCID 51030104HCID 51030104, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A quantity of 2 g of 5-[3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl]-2,4-dimethylbenzenesulphonyl chloride is dissolved in 25 ml of glacial acetic acid, and 4.6 ml of 32% strength hydrochloric acid are added. The mixture is heated to reflux temperature (120° C.). Then 2.53 g of iron powder are added in portions. Following complete reaction, the major fraction of the glacial acetic acid is removed by distillation, and water and dichloromethane are added. Following phase separation and concentration of the organic phase on a rotary evaporator, 1.3 g (80% of theory) of a beige solid are obtained.

Workup

  1. temperatureThe mixture is heated
  2. customreaction
  3. customthe major fraction of the glacial acetic acid is removed by distillation, and water and dichloromethane
  4. additionare added
  5. customFollowing phase separation and concentration of the organic phase
  6. customon a rotary evaporator, 1.3 g (80% of theory) of a beige solid
  7. customare obtained

Sources & evidence

ORD record
ord-2140badab74c490ab883e684e192d56b
Source dataset
uspto-grants-2014_05
Patent number
US08722717B2

Reaction notes

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