Tetrahydrofuran → HCID 59191363, compound

HRID 1023940Notes

Reaction equation

HRID 1023940 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2[F:19])=[C:5]([O:20][CH3:21])[CH:4]=1)[CH3:2].O1CC[CH2:24][CH2:23]1>C(O)C>[CH2:23]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:6]2[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[CH:4][C:5]=2[O:20][CH3:21])=[C:11]([F:19])[CH:12]=1)[CH3:24]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 59191258HCID 59191258, compound

Product 1

HCID 59191363HCID 59191363, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the procedure of example 20(b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl)phenoxy]benzene for 4-ethyl-1-(2-fluoro-4-nitrophenoxy)-2-methoxybenzene (1.16 g; 4.0 mmol) and tetrahydrofurane for ethanol (16 mL), two compounds were obtained after purification on silica gel (gradient cyclohexane/dichloromethane) 4-(4-ethyl-2-methoxyphenoxy)-3-fluoroaniline (466 mg; 45%)

Workup

  1. customtwo compounds were obtained
  2. customafter purification on silica gel (gradient cyclohexane/dichloromethane) 4-(4-ethyl-2-methoxyphenoxy)-3-fluoroaniline (466 mg; 45%)

Sources & evidence

ORD record
ord-2802a45a37dc493db7a39cfe87a22203
Source dataset
uspto-grants-2014_05
Patent number
US08722746B2

Reaction notes

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