Ammonia → HCID 59191207, compound

HRID 1023966Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:26]=[C:25]([CH2:27][CH3:28])[CH:24]=[CH:23][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][C:13]=1[F:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N.[CH2:30]([NH2:33])[CH2:31][CH3:32]>>[CH2:1]([O:8][C:9]1[CH:26]=[C:25]([CH2:27][CH3:28])[CH:24]=[CH:23][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:33][CH2:30][CH2:31][CH3:32])(=[O:20])=[O:19])=[CH:14][C:13]=1[F:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 222Ammonia

HCID 7852Propylamine

HCID 59191297HCID 59191297, compound

Product 1

HCID 59191207HCID 59191207, compoundYield 41%

Procedure

According to the procedure of example 65(b) except substituting 4-(4-ethyl-2-methoxyphenoxy)-3-fluorobenzene sulfonyl chloride for 4-[2-(benzyloxy)-4-ethylphenoxy]-3-fluorobenzene sulfonyl chloride and NH3 for propylamine (1.7 mmol; 0.14 mL), the title compound (140 mg; 0.32 mmol; 41%) was obtained as a brown oil after purification on preparative TLC (dichloromethane).

Sources & evidence

ORD record: ord-7b1c162527e3499095ac13e9d2e1894b
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722746B2

Reaction notes

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