Tetrahydrofuran → HCID 59191412, compound

HRID 1023967Notes

Reaction equation

HRID 1023967 reaction equation
C([O:8][C:9]1[CH:29]=[C:28]([CH2:30][CH3:31])[CH:27]=[CH:26][C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][CH3:24])(=[O:20])=[O:19])=[CH:14][C:13]=1[F:25])C1C=CC=CC=1.O1CCCC1>C(O)C>[CH2:30]([C:28]1[CH:27]=[CH:26][C:10]([O:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][CH3:24])(=[O:20])=[O:19])=[CH:14][C:13]=2[F:25])=[C:9]([OH:8])[CH:29]=1)[CH3:31]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 59191207HCID 59191207, compound

Product 1

HCID 59191412HCID 59191412, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the procedure of example 20(b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl)phenoxy]benzene for 4-(2-Benzyloxy-4-ethyl-phenoxy)-3-fluoro-N-propyl-benzenesulfonamide (140 mg; 0.32 mmol) and tetrahydrofurane for ethanol (3 mL), the title compound (70 mg; 62%) was obtained as a clear oil, after purification on preparative TLC (dichloromethane)

Sources & evidence

ORD record
ord-425c40518f484db0a4936c8d74828b65
Source dataset
uspto-grants-2014_05
Patent number
US08722746B2

Reaction notes

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