Tetrahydrofuran → HCID 59191341, compound

HRID 1023988Notes

Reaction equation

HRID 1023988 reaction equation
[F:1][C:2]1[CH:24]=[C:23]([N+:25]([O-])=O)[CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:7][C:6]=1[O:19][CH3:20].C1COCC1>C(O)C>[F:1][C:2]1[CH:24]=[C:23]([CH:22]=[CH:21][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:7][C:6]=1[O:19][CH3:20])[NH2:25]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 59191301HCID 59191301, compound

Product 1

HCID 59191341HCID 59191341, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the procedure of example 20(b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl)phenoxy]benzene by 2-{[4-(2-fluoro-4-nitrophenoxy)-3-methoxy phenyl]ethynyl}pyridine (0.23 mmol; 84 mg) and THF by ethanol, the title compound was obtained as a clear oil (68%, 53 mg) 10 after purification on preparative TLC (cyclohexane/ethyl acetate: 6/4).

Sources & evidence

ORD record
ord-726aafa15db848c480ecdc7cdf61f812
Source dataset
uspto-grants-2014_05
Patent number
US08722746B2

Reaction notes

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