反应详情

温度

80 °C

A mixture of 117b (2.05 g, 5.0 mmol), 117e (1.17 g, 5.0 mmol), and triethylamine (1.01 g, 10 mmol) in i-propanol (30 mL) was stirred at 80° C. for 4 h. It was then filtered and the filtrate was evaporated in vacuo. The residue was purified by silica-gel column chromatography eluting with 30:1 dichloromethane/methanol to afford 117f (1.82 g, 60%) as a yellow solid. MS-ESI: [M+H]+ 608.1

1. filtrationIt was then filtered
2. customthe filtrate was evaporated in vacuo
3. customThe residue was purified by silica-gel column chromatography
4. washeluting with 30:1 dichloromethane/methanol