HRID1024098

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(=O)OCc1c(-c2nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c3ncn(COCC[Si](C)(C)C)c3n2)cc(F)cc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O

HCID86684163

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCc1c(-c2nc(Nc3ccc(N4CCN(C5COC5)CC4)cc3)c3nc[nH]c3n2)cc(F)cc1N1CCn2c(cc3c2CC(C)(C)C3)C1=O

HCID178475813

未命名化合物

收率 90%

PROCEDURE

实验过程

A mixture of 123a (200 mg, 0.25 mmol) and CF3COOH (4 mL) was stirred at room temperature for 2 h. The mixture was then concentrated under reduced pressure to afford crude 123b as a yellow solid (160 mg, 90%), which was used for the next step without further purification. MS-ESI: [M+H]+ 720.4

WORKUP

后处理

concentrationThe mixture was then concentrated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db8b914c7ed9493f87dc493c7a356fe9
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08722676B2
来源说明: uspto-grants-2014_05

反应 SMILES

[C:1]([O:4][CH2:5][C:6]1[C:11]([C:12]2[N:20]=[C:19]3[C:15]([N:16]=[CH:17][N:18]3COCC[Si](C)(C)C)=[C:14]([NH:29][C:30]3[CH:35]=[CH:34][C:33]([N:36]4[CH2:41][CH2:40][N:39]([CH:42]5[CH2:45][O:44][CH2:43]5)[CH2:38][CH2:37]4)=[CH:32][CH:31]=3)[N:13]=2)=[CH:10][C:9]([F:46])=[CH:8][C:7]=1[N:47]1[CH2:58][CH2:57][N:56]2[C:49](=[CH:50][C:51]3[CH2:52][C:53]([CH3:60])([CH3:59])[CH2:54][C:55]=32)[C:48]1=[O:61])(=[O:3])[CH3:2].C(O)(C(F)(F)F)=O>>[C:1]([O:4][CH2:5][C:6]1[C:11]([C:12]2[N:20]=[C:19]3[C:15]([N:16]=[CH:17][NH:18]3)=[C:14]([NH:29][C:30]3[CH:35]=[CH:34][C:33]([N:36]4[CH2:37][CH2:38][N:39]([CH:42]5[CH2:43][O:44][CH2:45]5)[CH2:40][CH2:41]4)=[CH:32][CH:31]=3)[N:13]=2)=[CH:10][C:9]([F:46])=[CH:8][C:7]=1[N:47]1[CH2:58][CH2:57][N:56]2[C:49](=[CH:50][C:51]3[CH2:52][C:53]([CH3:60])([CH3:59])[CH2:54][C:55]=32)[C:48]1=[O:61])(=[O:3])[CH3:2]