Hydrochloric Acid → HCID 145734634, compound

HRID 1024416Notes

Reaction equation

HRID 1024416 reaction equation
[OH-].[Na+].[CH2:3]([C:10]1[C:18]2[C:13](=[CH:14][C:15]([OH:23])=[C:16]([C:19]([O:21]C)=[O:20])[CH:17]=2)[NH:12][N:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO.O>[CH2:3]([C:10]1[C:18]2[C:13](=[CH:14][C:15]([OH:23])=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=2)[NH:12][N:11]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 148550297HCID 148550297, compound

Product 1

HCID 145734634HCID 145734634, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

1.4 595 μl of 2 N NaOH are added to a suspension of 112 mg of “A1” in 1.5 ml of methanol, and the mixture is stirred at 60° for 3 hours. The mixture is cooled, 0.7 ml of 2 N HCl is added, the mixture is diluted with water, the precipitate is removed, and the mixture is subjected to conventional work-up, giving 75 mg of 3-benzyl-6-hydroxy-1H-indazole-5-carboxylic acid (“A2”).

Workup

  1. temperatureThe mixture is cooled
  2. customthe precipitate is removed

Sources & evidence

ORD record
ord-179e0d5d770b4722b2702536799b1ca9
Source dataset
uspto-grants-2014_05
Patent number
US08722903B2

Reaction notes

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