Water → 4-(4-Chlorophenyl)-2-methoxybenzoic acid

HRID 1024530Notes

Reaction equation

HRID 1024530 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:7][C:6]=1[O:18][CH3:19])=[O:4].O.[Li+].[OH-]>C1COCC1>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[C:6]([O:18][CH3:19])[CH:7]=2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 595130824'-Chloro-3-methoxy-biphenyl-4-carboxylic acid methyl ester

Product 1

HCID 248911994-(4-Chlorophenyl)-2-methoxybenzoic acidYield 91%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4′-chloro-3-methoxy-biphenyl-4-carboxylic acid methyl ester, 30, (0.615 g, 2.22 mmol) in THF (20 mL) and H2O (5 mL) is added LiOH (0.932 g, 22.2 mmol). The resulting suspension is heated to reflux for 2 hours. The reaction is cooled and concentrated under reduced pressure. The crude product is acidified using conc. HCl and the resulting solid is collected by filtration, washed with H2O to afford 0.532 g (91% yield) of the desired compound as a grey solid. 1H NMR (400 MHz, CDCl3) δ ppm 10.69 (1H, br s), 8.26 (1H, d, J=8.1 Hz), 7.53-7.58 (2H, m), 7.44-7.50 (2H, m), 7.33 (1H, dd, J=8.1, 1.6 Hz), 7.20 (1H, d, J=1.3 Hz), 4.17 (3H, s). HPLC-MS: m/z 263 [M+H]+.

Workup

  1. temperatureThe resulting suspension is heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe reaction is cooled
  4. concentrationconcentrated under reduced pressure
  5. filtrationthe resulting solid is collected by filtration
  6. washwashed with H2O

Sources & evidence

ORD record
ord-436d5f8a72414c8b9e468f626596aa42
Source dataset
uspto-grants-2014_05
Patent number
US08722895B2

Reaction notes

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