2-Bromoethanol → HCID 66818769, compound

HRID 1024814Notes

Reaction equation

HRID 1024814 reaction equation
[C:1]([C:3]1[CH:33]=[CH:32][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:20]=[C:21]([O:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)[CH:22]=2)[C:11]([NH:13][CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[O:12])=[CH:5][CH:4]=1)#[N:2].Br[CH2:35][CH2:36][OH:37]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:20]=[C:21]([O:23][C:24]3[CH:25]=[CH:26][C:27]([C:30]#[N:31])=[CH:28][CH:29]=3)[CH:22]=2)[C:11]([NH:13][CH:14]2[CH2:15][CH2:16][N:17]([CH2:35][CH2:36][OH:37])[CH2:18][CH2:19]2)=[O:12])=[CH:32][CH:33]=1)#[N:2]

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 66818786HCID 66818786, compound

Product 1

HCID 66818769HCID 66818769, compoundYield 72.7%

Procedure

Following procedure of Example 11(e) 3,5-bis-(4-cyano-phenoxy)-N-piperidin-4-yl-benzamide 0.5 g (1.14 mmol) and 2-bromoethanol (0.214 g, 1.71 mmol) were used to afford 0.4 g of the required product. Percentage purity (LCMS): 76.2%, (M+1)=482+1.

Sources & evidence

ORD record
ord-81cfea82adbf43569d2dfb8813017baf
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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