Hydrochloric Acid → 1-(Pyridazin-3-yl)cyclopropanamine hydrochloride

HRID 1025232Notes

Reaction equation

HRID 1025232 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[N:2]=1.[ClH:18]>C1COCC1.O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([NH2:10])[CH2:9][CH2:8]2)[N:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67291864Tert-butyl 1-(pyridazin-3-yl)cyclopropylcarbamate

Product 1

HCID 672914801-(Pyridazin-3-yl)cyclopropanamine hydrochloride

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 1-(pyridazin-3-yl)cyclopropylcarbamate (0.3 g) in THF (3 ml) at 0° C. was added HCl in dioxane (5 ml) and the mixture stirred at r.t. for 3 hr. The reaction mixture was concentrated, and the crude product was taken for the next coupling reaction. Yield: 0.21 g

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product was taken for the next coupling reaction

Sources & evidence

ORD record
ord-8bba017bfafe41da8ef57042adcdc905
Source dataset
uspto-grants-2014_05
Patent number
US08722688B2

Reaction notes

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