Isopropylamine → HCID 68207821, compound

HRID 1025418Notes

Reaction equation

HRID 1025418 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].[CH:13]([NH2:16])([CH3:15])[CH3:14]>CN(C=O)C>[CH:13]([NH:16][CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 517981Methyl 3-(bromomethyl)benzoate

Product 1

HCID 68207821HCID 68207821, compoundYield 66.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2.00 g of methyl 3-(bromomethyl)benzoate, 1.55 g of isopropylamine, and 10 mL of DMF was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (chloroform-methanol) to obtain 1.20 g of methyl 3-[(isopropylamino)methyl]benzoate as a colorless solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (chloroform-methanol)

Sources & evidence

ORD record
ord-0a86009b9b98468abb83647f7c1ae0d7
Source dataset
uspto-grants-2014_05
Patent number
US08729068B2

Reaction notes

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