反应详情

温度

170 °C

To a stirred solution of 1-bromo-4-chloro-imidazo[1,2-a]quinoxaline (14.13 g, 50 mmol) in NMP (400 mL) was added isobutylamine (9.94 mL, 100 mmol) and DIPEA (26.13 mL, 150 mmol) at room temperature in a microwave reactor. The solution was heated at 170° C. under microwave irradiation for 60 min. After cooling, water was added to the solution and the precipitate was filtered and the residue was washed with water and dried to give (1-bromo-imidazo[1,2-a]quinoxalin-4-yl)-isobutyl-amine (14.89 g, 93.3%): 1H-NMR (300 MHz, d6-DMSO): δ=9.17 (1H, d), 8.01 (1H, d), 7.92 (1H, s), 7.78 (1H, dd), 7.70 (1H, dd) ppm. UPLC-MS: RT=1.14 min; m/z 284.6 [MH+]; required MW=283.5.

1. temperatureAfter cooling
2. filtrationthe precipitate was filtered
3. washthe residue was washed with water
4. customdried