反应详情

A solution of 2,4-dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine (0.76 g, 2.58 mmol) and sodium hydroxide (2.6 ml, 1N) in THF (30 mL) was heated at 50° C. for 1 hour. 1N HCl (3 ml) was added and the mixture was extracted with ethyl acetate. The organic layer was dried and concentrated to provide 0.73 g of 2-chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ol which was characterized by its mass spectrum as follows: MS (m/z) 276 [M+H]+.

1. extractionthe mixture was extracted with ethyl acetate
2. customThe organic layer was dried
3. concentrationconcentrated