反应详情

To the product from step A (190 mmol, 44 g) in THF (200 mL) was added HCl solution (300 mmol, 100 mL). The reaction was stirred over 2 days after which the reaction was washed using diethyl ether. The aqueous layer was then quenched using NaOH (50%) to obtain a pH of 11. The aqueous layer was extracted using EtOAc (6×300 mL). The organic layer was combined and dried over MgSO4 and concentrated in vacuo. The residue was purified via flash chromatography to afford the desired ketone (18 g, 49%). MS [M+H]+ 193.1

1. washwas washed
2. customThe aqueous layer was then quenched
3. customto obtain a pH of 11
4. extractionThe aqueous layer was extracted
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo
7. customThe residue was purified via flash chromatography