Methanol → HCID 67778809, compound

HRID 1026229Notes

Reaction equation

HRID 1026229 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH:23]=[C:22]3[C:17]([CH:18]=[CH:19][C:20]([O:24][CH3:25])=[CH:21]3)=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.CO>[Pd].C1COCC1>[CH3:25][O:24][C:20]1[CH:19]=[CH:18][C:17]2[C:22](=[CH:23][N:15]([C:12]3[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=3)[N:16]=2)[CH:21]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 67776616HCID 67776616, compound

Product 1

HCID 67778809HCID 67778809, compoundYield 104%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Under a hydrogen atmosphere, a mixture of 2-[4-(benzyloxy)phenyl]-5-methoxy-2H-indazole (160 mg), 10% palladium/carbon (containing water (50%), 52 mg), methanol (10 mL) and THF (5 mL) was stirred at room temperature for 1 hr. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (121 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f22c9f014d074c94bc209b2ebc25d6c6
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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