Iodoethane → tert-butyl [(1S)-2-{[6-(6-ethoxy-1,3-benzoxazol-2-yl)-5-fluoropyridin-3-yl]oxy}-1-methylethyl]carbamate
Reaction equation
O[C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[N:17]=[CH:16][C:15]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])=[CH:14][C:13]=1[F:30])=[O:11].[CH2:31](I)[CH3:32]>>[CH2:31]([O:8][C:6]1[CH:7]=[CH:2][C:3]2[N:9]=[C:10]([C:12]3[N:17]=[CH:16][C:15]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:26])[CH3:27])[CH3:21])=[CH:14][C:13]=3[F:30])[O:11][C:4]=2[CH:5]=1)[CH3:32]Participants
3
Procedure
Using tert-butyl [(1S)-2-({6-[(2,4-dihydroxyphenyl)carbamoyl]-5-fluoropyridin-3-yl}oxy)-1-methylethyl]carbamate and ethyl iodide, and in the same manner as in Example 2, steps D-E, the title compound was obtained.
Sources & evidence
- ORD record
- ord-5aaf32e398174ec0a2f6b68e70c6f046
- Source dataset
- uspto-grants-2014_05
- Patent number
- US08729102B2
Reaction notes
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