Triethylamine → HCID 11374585, compound

HRID 1026661Notes

Reaction equation

HRID 1026661 reaction equation
[F:1][C:2]1([CH2:26][NH2:27])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][C:9]=2[F:25])[CH2:4][CH2:3]1.[CH3:28][S:29](Cl)(=[O:31])=[O:30].C(N(CC)CC)C>ClCCl>[F:1][C:2]1([CH2:26][NH:27][S:29]([CH3:28])(=[O:31])=[O:30])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][C:9]=2[F:25])[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 11394934HCID 11394934, compound

Product 1

HCID 11374585HCID 11374585, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by reacting (S)—N-{3-[4-(4-fluoro-4-aminomethyl piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.30 mmol) with methane sulfonyl chloride (1.40 mmol) and triethylamine (2.08 mmol) in dichloromethane (10 ml) at a temperature 25° C. for 2 hours followed by purification of the compound using silica gel column chromatography in 75% yield.

Workup

  1. customat a temperature 25° C.
  2. customfor 2 hours
  3. customfollowed by purification of the compound

Sources & evidence

ORD record
ord-2e7768da33b444a4b1bcb30f1ea88395
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

Loading…