Sodium ethoxide → HCID 11429747, compound

HRID 1026683Notes

Reaction equation

HRID 1026683 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:2]1.[O-:27][CH2:28][CH3:29].[Na+]>C(O)C>[CH2:28]([O:27][CH2:2][C:3]1([OH:1])[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]3=[O:25])=[CH:11][C:10]=2[F:26])[CH2:5][CH2:4]1)[CH3:29]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 11382912HCID 11382912, compound

Product 1

HCID 11429747HCID 11429747, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared by reacting (S)—N-{3-[4-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.0 mmol) with sodium ethoxide (1.6 mmol) in ethanol (10 ml) at a temperature 60° C. for 6 hours and by purifying the compound by silica gel column chromatography in 55% yield.

Workup

  1. customat a temperature 60° C.
  2. customfor 6 hours
  3. customby purifying the compound by silica gel column chromatography in 55% yield

Sources & evidence

ORD record
ord-7528523b9fc04656a223a45a26843888
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

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