Hydrogen chloride-ethyl acetate → HCID 86690485, compound

HRID 1026761Notes

Reaction equation

HRID 1026761 reaction equation
[CH:1]1([N:5]([C:14]([C:16]2[N:17]=[CH:18][N:19]([CH3:21])[CH:20]=2)=[O:15])[CH2:6][C:7]([O:9]C(C)(C)C)=[O:8])[CH2:4][CH2:3][CH2:2]1.[ClH:22].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:22].[CH:1]1([N:5]([C:14]([C:16]2[N:17]=[CH:18][N:19]([CH3:21])[CH:20]=2)=[O:15])[CH2:6][C:7]([OH:9])=[O:8])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86690487HCID 86690487, compound

Product 1

HCID 86690485HCID 86690485, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl N-cyclobutyl-N-[(1-methyl-1H-imidazol-4-yl)carbonyl]glycinate (200 mg) in ethyl acetate (4 mL) was added 4N hydrochloric acid/ethyl acetate solution (4 mL), and the mixture was stirred at room temperature overnight. The solvent was distilled off under reduced pressure to afford N-cyclobutyl-N-[(1-methyl-1H-imidazol-4-yl)carbonyl]glycine hydrochloride (150 mg).

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-48d11973b5b64a799e99732e193b8aa6
Source dataset
uspto-grants-2014_05
Patent number
US08729271B2

Reaction notes

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