反应详情

温度

95 °C

Methyl 7-benzylamino-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylate (6.4 g, 17.7 mmol) obtained in step 3 was dissolved in pyridine (90 mL), lithium iodide (23.7 g, 0.18 mol) was added, and the mixture was stirred with heating at 95° C. for 4 hr. The reaction mixture was allowed to cool, added dropwise to 2 mol/L hydrochloric acid containing ice (about 500 mL), and the mixture was stirred at room temperature for 1 hr. The precipitated solid was collected by filtration, washed with isopropanol (100 mL), and dried under reduced pressure at 50° C. overnight to give the title compound (5.2 g, 85%).

1. temperatureto cool
2. stirringthe mixture was stirred at room temperature for 1 hr
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with isopropanol (100 mL)
5. customdried under reduced pressure at 50° C. overnight