反应详情

温度

120 °C

Following GENERAL METHOD 6-1 for SNAr, Intermediate 2-1 (50 mg, 0.174 mmol), tert-butyl piperazine-1-carboxylate (59 mg, 0.314 mmol), DIPEA (0.06 mL, 0.349 mmol), and n-butanol (0.1 mL) were combined in a 4 mL reaction vial and heated at 120° C. overnight. The reaction was cooled to RT and EtOAc was added. The white solid that formed was filtered off and washed with EtOAc, dissolved in DCM and washed with H2O. The organic layer was dried with sodium sulfate, filtered, and concentrated in vacuo to afford the desired product.

1. customwere combined in a 4 mL reaction vial
2. temperatureThe reaction was cooled to RT
3. customThe white solid that formed
4. filtrationwas filtered off
5. washwashed with EtOAc
6. dissolutiondissolved in DCM
7. washwashed with H2O
8. dry with materialThe organic layer was dried with sodium sulfate
9. filtrationfiltered
10. concentrationconcentrated in vacuo