反应详情

温度

60 °C

26.2 g of potassium carbonate and 6.4 g of 1-bromo-propane were added to a solution of 15 g of 2-(2-chloro-5-fluoro-phenyl)-5-methyl-6H-oxazolo[5,4-d]pyrimidin-7-one in 150 ml of dimethylformamide. The suspension was stirred at 60° C. for 72 h. After cooling, the mixture was poured onto 300 ml of water. The precipitate was filtered off by suction. The obtained mixture of regioisomers was separated by silica gel chromatography (method SC1). Besides 3.3 g of 2-(2-chloro-5-fluoro-phenyl)-5-methyl-6-propyl-6H-oxazolo[5,4-d]pyrimidin-7-one, 3.2 g of the title compound were obtained.

1. temperatureAfter cooling
2. filtrationThe precipitate was filtered off by suction
3. additionThe obtained mixture of regioisomers
4. customwas separated by silica gel chromatography (method SC1)