HCID 67175763, compound → HCID 44602496, compound

HRID 1027492Notes

Reaction equation

HRID 1027492 reaction equation
[Cl:1][C:2]1[CH:38]=[CH:37][C:5]([CH2:6][C:7]2[N:8]=[C:9]([O:33][CH2:34][CH2:35][CH3:36])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([O:23][CH2:24][CH:25]5[CH2:29][O:28]C(C)(C)[O:26]5)=[C:18]([CH3:32])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1>ClCCl.FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[N:8]=[C:9]([O:33][CH2:34][CH2:35][CH3:36])[C:10]3[N:15]=[C:14]([C:16]4[CH:17]=[C:18]([CH3:32])[C:19]([O:23][CH2:24][CH:25]([OH:26])[CH2:29][OH:28])=[C:20]([CH3:22])[CH:21]=4)[O:13][C:11]=3[N:12]=2)=[CH:37][CH:38]=1

Participants

4

Reactant 1

HCID 67175763HCID 67175763, compound

Product 1

HCID 44602496HCID 44602496, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

The 5-(4-chloro-benzyl)-2-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3,5-dimethyl-phenyl]-7-propoxy-oxazolo[5,4-d]pyrimidine obtained in step (a) was dissolved in 6 ml of dichloromethane and 2 ml of trifluoroacetic acid. The reaction mixture was stirred for 2 h at room temperature. Then the solvents were removed in vacuo and the residue was purified by preparative HPLC (method HPLC1). 4.1 mg of the title compound were obtained.

Workup

  1. customThen the solvents were removed in vacuo
  2. customthe residue was purified by preparative HPLC (method HPLC1)

Sources & evidence

ORD record
ord-1c430c0b550b491189b340205996a255
Source dataset
uspto-grants-2014_05
Patent number
US08735387B2

Reaction notes

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