Water → HCID 58382517, compound

HRID 1027502Notes

Reaction equation

HRID 1027502 reaction equation
C([O:5][C:6](=[O:38])[CH2:7][O:8][C:9]1[C:14]([CH3:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[N:19]=[C:20]([CH2:29][C:30]4[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=4)[N:21]=[C:22]([O:25][CH2:26][CH2:27][CH3:28])[C:23]=3[N:24]=2)=[CH:11][C:10]=1[CH3:37])(C)(C)C.O>FC(F)(F)C(O)=O>[Cl:36][C:33]1[CH:34]=[CH:35][C:30]([CH2:29][C:20]2[N:21]=[C:22]([O:25][CH2:26][CH2:27][CH3:28])[C:23]3[N:24]=[C:16]([C:12]4[CH:13]=[C:14]([CH3:15])[C:9]([O:8][CH2:7][C:6]([OH:38])=[O:5])=[C:10]([CH3:37])[CH:11]=4)[O:17][C:18]=3[N:19]=2)=[CH:31][CH:32]=1

Participants

4

Reactant 2

HCID 962WaterHCID 67176584HCID 67176584, compound

Product 1

HCID 58382517HCID 58382517, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The crude {4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid tert-butyl ester obtained in step (a) was dissolved in trifluoroacetic acid and stirred for 3 h at room temperature. After addition of water the precipitate was isolated by filtration to yield 1.3 g of the crude title compound. 500 mg thereof were purified by preparative HPLC (method HPLC1) to yield 260 mg of the pure title compound.

Workup

  1. customwas isolated by filtration
  2. customto yield 1.3 g of the crude title compound
  3. custom500 mg thereof were purified by preparative HPLC (method HPLC1)

Sources & evidence

ORD record
ord-24c134768d554f06bb4ee935e8623c9e
Source dataset
uspto-grants-2014_05
Patent number
US08735387B2

Reaction notes

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