Trifluoroacetic acid → HCID 67246433, compound

HRID 1027584Notes

Reaction equation

HRID 1027584 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]1[O:13][N:12]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:14]([N:12]1[CH2:11][CH2:10][CH:9]([CH2:8][NH2:7])[O:13]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15384455HCID 15384455, compound

Product 1

HCID 67246433HCID 67246433, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2-benzyl-isoxazolidin-5-ylmethyl)-carbamic acid tert-butyl ester (Step A, 0.5 g) in dichloromethane (10 ml) was treated with trifluoroacetic acid (1.95 g). The solution was stirred at room temperature for 4 hours then concentrated in vacuo to afford the crude title product, which was used directly for the next step. LCMS (Method F) 0.20 min, M+H 194.

Workup

  1. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-898f86f6e4c34faf8f288b5596f240ef
Source dataset
uspto-grants-2014_05
Patent number
US08735362B2

Reaction notes

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