Water → HCID 86667461, compound

HRID 1027787Notes

Reaction equation

HRID 1027787 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][N:3]=1.N12CCN(CC1)CC2.[N:21]1([C:26](Cl)=[O:27])[CH2:25][CH2:24][CH2:23][CH2:22]1.O>CN(C)C=O>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([C:26]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:27])[C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 9237DabcoHCID 709371-Pyrrolidinecarbonyl chlorideHCID 82406358HCID 82406358, compound

Product 1

HCID 86667461HCID 86667461, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-chloro-9-methyl-7,9-dihydro-8H-purine-8-one <the compound of Reference Example 1> (3.0 g) in N,N-dimethylformamide (50 ml) were added 1,4-diazabicyclo[2.2.2]octane (5.5 g) and 1-pyrrolidine carbonyl chloride (2.7 ml) and the mixture was stirred for 1 hour. The reaction mixture was poured into cold water and the crystals precipitated were collected by filtration to give the title compound 3.0 g.

Workup

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-37bebdcc3abf490191b1b9a75e390bf6
Source dataset
uspto-grants-2014_05
Patent number
US08735406B2

Reaction notes

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