Dimethylformamide → HCID 68007512, compound

HRID 1027792Notes

Reaction equation

HRID 1027792 reaction equation
[C:1]1([C:7]2[N:15]=[C:14]3[C:10]([NH:11][C:12](=[O:16])[NH:13]3)=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N12CCN(CC1)CC2.CN(C)C=O.[N:30]1([C:35](Cl)=[O:36])[CH2:34][CH2:33][CH2:32][CH2:31]1>O>[C:1]1([C:7]2[N:15]=[C:14]3[C:10]([N:11]([C:35]([N:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)=[O:36])[C:12](=[O:16])[NH:13]3)=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 9237DabcoHCID 709371-Pyrrolidinecarbonyl chlorideHCID 67317994HCID 67317994, compound

Product 1

HCID 68007512HCID 68007512, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 2-phenyl-7,9-dihydro-8H-purine-8-one <prepared according to the similar method to those of Reference Example 19> (4.0 g), 1,4-diazabicyclo[2.2.2]octane (2.2 g) and N,N-dimethylformamide (50 ml) was added dropwise 1-pyrrolidinecarbonyl chloride (2.6 g) at room temperature and the mixture was stirred for 10 hours. To the reaction mixture was added water (100 ml), and the crystals precipitated were collected by filtration and was dried to give the title compound 4.8 g.

Workup

  1. customprepared
  2. customthe crystals precipitated
  3. filtrationwere collected by filtration
  4. customwas dried

Sources & evidence

ORD record
ord-abe25e922896462a90157831ee93e778
Source dataset
uspto-grants-2014_05
Patent number
US08735406B2

Reaction notes

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