反应详情

温度

80 °C

0.97 ml of 4N solution of hydrogen chloride in dioxane was added to 1.40 g (3.88 mmol) of 4-((1R,2R)-2-benzyloxy-1-methyl-propoxy)-2-chloro-5-trifluoromethyl-pyrimidine and 1.20 g (4.51 mmol) (RS)-S-(4-aminophenyl)-S-methyl-N-(trifluoroacetyl)sulfoximide in 19.0 ml acetonitrile and was then stirred for 6 hours at 80° C. After cooling, the mixture was diluted with ethyl acetate and washed with saturated sodium hydrogencarbonate solution and saturated sodium chloride solution, dried (Na2SO4), filtered and concentrated by evaporation. The residue is obtained was purified chromatographically (hexane/ethyl acetate 1:1). 1.76 g (2.98 mmol, yield: 77%) of the product was obtained.

1. temperatureAfter cooling
2. washwashed with saturated sodium hydrogencarbonate solution and saturated sodium chloride solution
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated by evaporation
6. customThe residue is obtained
7. customwas purified chromatographically (hexane/ethyl acetate 1:1)