Trifluoroacetic acid → 6-Benzyl-2,6-diazaspiro[3.5]nonane 2,2,2-trifluoroacetate

HRID 1027886Notes

Reaction equation

[CH2:1]([N:8]1[CH2:23][CH2:22][CH2:21][C:10]2([CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>C(Cl)Cl>[F:27][C:26]([F:29])([F:28])[C:24]([OH:30])=[O:25].[CH2:1]([N:8]1[CH2:23][CH2:22][CH2:21][C:10]2([CH2:13][NH:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 60 °C

Procedure

tert-butyl 6-benzyl-2,6-diazaspiro[3.5]nonane-2-carboxylate (0.18 g) was mixed with CH2Cl2 (1 mL) and TFA (1 mL), then heated at 60° C. for 2 minutes and concentrated to dryness to provide the title compound as the trifluoroacetic acid salt.

Workup

concentrationconcentrated to dryness

Sources & evidence

ORD record: ord-f6d483192b19417ebf13968c9f6dfb1c
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08735411B2

Reaction notes

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