HCID 59637336, compound → HCID 59637291, compound

HRID 1027967Notes

Reaction equation

HRID 1027967 reaction equation
[CH:1]1([CH:7]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[C:15]([F:22])[CH:14]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CCO.CC(=O)OCC>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([CH:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:14][C:15]=1[F:22]

Participants

4

Reactant 1

HCID 59637336HCID 59637336, compound

Product 1

HCID 59637291HCID 59637291, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Ethyl 2-cyclohexyl-2-(3-fluoro-4-nitrophenyl)acetate was dissolved in a 1:1 mixture of EtOH and EA (420 mL) and hydrogenation was carried out in an H-cube (1 bar, 25° C., 1 mL/min and 0.25 mol/L). Following removal of the solvent and drying, 5 g of the desired product were obtained (quantitative conversion).

Workup

  1. customwas carried out in an H-cube (1 bar, 25° C., 1 mL/min and 0.25 mol/L)
  2. customremoval of the solvent
  3. customdrying

Sources & evidence

ORD record
ord-7e7d883b4f43452d9961155ec486cbf3
Source dataset
uspto-grants-2014_05
Patent number
US08735426B2

Reaction notes

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