HCID 59637316, compound → HCID 59637311, compound

HRID 1027970Notes

Reaction equation

HRID 1027970 reaction equation
[C:1]1([CH:7]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[C:15]([F:22])[CH:14]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CCO.CC(=O)OCC>[CH2:11]([O:10][C:8](=[O:9])[CH:7]([C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[C:15]([F:22])[CH:14]=1)[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:12]

Participants

4

Reactant 1

HCID 59637316HCID 59637316, compound

Product 1

HCID 59637311HCID 59637311, compoundYield 97.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Ethyl 2-phenyl-2-(3-fluoro-4-nitrophenyl)acetate was dissolved in a 1:1 mixture of EtOH and EA (465 mL) and hydrogenation was carried out in an H-cube (1 bar, 25° C., 1 mL/min and 0.25 mol/L). Following removal of the solvent and drying, 5.2 g (97.5%) of product were obtained.

Workup

  1. customwas carried out in an H-cube (1 bar, 25° C., 1 mL/min and 0.25 mol/L)
  2. customremoval of the solvent
  3. customdrying

Sources & evidence

ORD record
ord-504da8a34350489fa7b90d17a3d30252
Source dataset
uspto-grants-2014_05
Patent number
US08735426B2

Reaction notes

Loading…