m-Chloroperbenzoic acid → HCID 86650329, compound

HRID 1028453Notes

Reaction equation

HRID 1028453 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][N:9]=1.C1C=C([Cl:24])C=C(C(OO)=O)C=1>CCOC(C)=O>[Cl:24][C:10]1[CH:11]=[C:12]([C:14]([F:17])([F:15])[F:16])[CH:13]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[N:9]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 66862833HCID 66862833, compound

Product 1

HCID 86650329HCID 86650329, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 2-(2-chlorophenyl)-4-(trifluoromethyl)pyridine (5.40 g, 21.0 mmol) in EtOAc (100 mL) was added mCPBA (7.25 g, 42.0 mmol) in EtOAc (100 mL) over 30 min and then the mixture was heated at reflux (caution: use shield) for 3 h. The reaction mixture was cooled and then washed twice with sat. aq. NaHCO3 and concentrated.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux (caution: use shield) for 3 h
  3. temperatureThe reaction mixture was cooled
  4. washwashed twice with sat. aq. NaHCO3
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-e124e49c8a284e178c406c9742df1f18
Source dataset
uspto-grants-2014_05
Patent number
US08735593B2

Reaction notes

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