2,5-Dimethoxyaniline → HCID 58168212, compound

HRID 1029164Notes

Reaction equation

HRID 1029164 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2.[CH3:17][O:18][C:19]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:20]=1[NH2:21]>>[CH3:17][O:18][C:19]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:20]=1[NH:21][C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6](=[O:12])[NH:7]2

Participants

3

Reactant 2

HCID 76132,5-DimethoxyanilineHCID 581680081-Chlorobenzo[C][1,8]naphthyridin-6(5H)-one

Product 1

HCID 58168212HCID 58168212, compoundYield 76.3%

Procedure

The title compound was synthesized according to the procedure described for the preparation of Example 188 using Compound 83 (100 mg, 0.43 mmol) and 2,5-di-methoxyaniline (133 mg, 0.87 mmol) to provide 200 (114 mg, 76% yield) as a white solid. LC-MS (M+H=348, obsd.=348).

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-d5cd69fa26cb4d7cb406d5e242caeec4
Source dataset
uspto-grants-2014_05
Patent number
US08735584B2

Reaction notes

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