反应详情

70 (172 mg, 0.81 mmol), methyl 4-(bromomethyl)benzoate (205 mg, 0.89 mmol), and K2CO3 (225 mg, 1.63 mmol) were suspended in DMF (3.00 mL), and stirred overnight at room temperature. The reaction mixture was purified directly via flash chromatography on silica gel to provide 454 (34 mg, 11% yield) as a white powder. LC-MS (M+H=360, obsd.=360). 1H NMR (400 MHz, DMSO-D6) δ 11.49 (s, 1H), 8.51 (m, 1H), 8.41 (d, J=3.0, 1H), 7.97 (dd, J=8.6, 19.3, 2H), 7.58 (d, J=8.2, 2H), 7.38 (m, 1H), 7.37 (s, 1H), 7.24 (dd, J=4.7, 7.9, 1H), 6.95 (d, J=11.0, 1H), 4.62 (s, 2H), 3.83 (s, 3H).

1. customThe reaction mixture was purified directly via flash chromatography on silica gel