Benzenesulfonyl chloride → HCID 53776801, compound

HRID 1029440Notes

Reaction equation

HRID 1029440 reaction equation
[OH:1][CH2:2][CH:3]1[CH:8]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH2:7][CH2:6][N:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:4]1.[C:19]1([S:25](Cl)(=[O:27])=[O:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(N(CC)CC)C.C1(S(OCC2C(C3SC=CC=3)CCN(C)C2)(=O)=O)C=CC=CC=1>C1(C)C=CC=CC=1>[C:19]1([S:25]([O:1][CH2:2][CH:3]2[CH:8]([C:9]3[S:10][CH:11]=[CH:12][CH:13]=3)[CH2:7][CH2:6][N:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:4]2)(=[O:27])=[O:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 4

HCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 19900552HCID 19900552, compoundHCID 54325241HCID 54325241, compound

Product 1

HCID 53776801HCID 53776801, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-benzenesulphonyloxymethyl-1-pentyl-4-(2-thienyl)-piperidine (14) was prepared from 3-hydroxymethyl-1-pentyl-4-(2-thienyl)piperidine (13 g), benzenesulphonyl chloride (13 ml) and triethylamine (12.5 ml) in dry toluene (100 ml) as described for (2). Yield: 20.4 g, mass spectrum (M+ 407) in accordance with proposed structure

Sources & evidence

ORD record
ord-eb84d94c9c8e4bd1a3d880ce3add9ad8
Source dataset
uspto-grants-1992_04
Patent number
US05102894

Reaction notes

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