Hydrochloric Acid → 3-Diisopropylaminopropionic acid hydrochloride

HRID 1029479Notes

Reaction equation

HRID 1029479 reaction equation
CN1CCCC(C(O)=O)C1.[CH:11]([N:14]([CH:22]([CH3:24])[CH3:23])[CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])([CH3:13])[CH3:12].[ClH:25]>>[ClH:25].[CH:22]([N:14]([CH:11]([CH3:13])[CH3:12])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])([CH3:24])[CH3:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27369371-methylpiperidine-3-carboxylic AcidHCID 15468050Ethyl 3-diisopropylaminopropionate

Product 1

HCID 867456233-Diisopropylaminopropionic acid hydrochloride

Procedure

3-Diisopropylaminopropionic acid hydrochloride may be obtained by working according to the method described in Example 4 for the preparation of 1-methyl-3-piperidinecarboxylic acid, but starting with ethyl 3-diisopropylaminopropionate (5 g) and 6N aqueous hydrochloric acid solution (35 cc). After the product obtained has been recrystallized in acetone, 3-diisopropylaminopropionic acid hydrochloride (2.3 g), m.p. 170° C., is obtained.

Workup

  1. customAfter the product obtained
  2. customhas been recrystallized in acetone

Sources & evidence

ORD record
ord-d5b63bbaf0944c59a6cb75fd9d679952
Source dataset
uspto-grants-1992_04
Patent number
US05102890

Reaction notes

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