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HRID1029483

反应详情

EQUATION

反应方程式

HRID 1029483 的结构方程式

REACTANTS

反应物

3
结构：CC(C)CCCC(=O)O
HCID12344

5-Methylhexanoic acid

C7H14O2

结构：C1CCC2=NCCCN2CC1
HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：O=C1c2ccccc2C(Cl)N1c1ccc2ccc(Cl)nc2n1
HCID14182404

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CCCC(=O)OC1c2ccccc2C(=O)N1c1ccc2ccc(Cl)nc2n1
HCID19900427

未命名化合物

收率 63%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Working as in Example 1, but starting with 3-chloro-2-(7-chloro-1,8-naphthyridin-2yl)-1-isoindolinone (9.9 g) in anhydrous dimethylformamide (100 cc), 5-methylhexanoic acid (3.9 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.6 g), and after recrystallization in ethanol, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate (8 g), m.p. 132° C., is obtained.

WORKUP

后处理

  1. customafter recrystallization in ethanol