反应详情

Working as in Example 1, but starting with 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (9.9 g) in anhydrous dimethylformamide (100 cc), 1-propionyl-4-piperidinecarboxylic acid (5.5 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.6 g), and by recrystallization in ethanol, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 1-propionyl-4-piperidinecarboxylate (4.9 g), m.p. 189° C., is obtained.

1. customby recrystallization in ethanol