Hydrochloric Acid → 3-(2,6-Dimethylpiperidino)propionic acid hydrochloride
Reaction equation
[ClH:1].CN1CCCC(C(O)=O)C1.Cl.[CH3:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH:16]([CH3:20])[N:15]1[CH2:21][CH2:22][C:23]([O:25]CC)=[O:24].Cl>>[ClH:1].[CH3:20][CH:16]1[CH2:17][CH2:18][CH2:19][CH:14]([CH3:13])[N:15]1[CH2:21][CH2:22][C:23]([OH:25])=[O:24]Participants
4
Procedure
3-(2,6-Dimethylpiperdino)propionic acid hydrochloride may be obtained by working according to the method described in Example 4 for the preparation of 1-methyl-3-piperidinecarboxylic acid hydrochloride, but starting with ethyl 3-(2,6-dimethylpiperidino)propionate hydrochloride (12.5 g) and 6N aqueous hydrochloric acid solution (35 cc). 3-(2,6-Dimethylpiperidino)propionic acid hydrochloride, m.p. 215° C., is thereby obtained.
Sources & evidence
- ORD record
- ord-6cc36dfa3e534811a4cf818624daac89
- Source dataset
- uspto-grants-1992_04
- Patent number
- US05102890
Reaction notes
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