Hydrazine hydrate (1:1) → HCID 19609556, compound

HRID 1029527Notes

Reaction equation

HRID 1029527 reaction equation
O.[NH2:2][NH2:3].[CH3:4][C:5]([C:8]1[CH:9]=[C:10]([S:19][CH2:20][CH2:21][C:22]([O:24]C)=O)[CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])([CH3:7])[CH3:6]>CO.C(OCC)(=O)C>[CH3:4][C:5]([C:8]1[CH:9]=[C:10]([S:19][CH2:20][CH2:21][C:22]([NH:2][NH2:3])=[O:24])[CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])([CH3:7])[CH3:6]

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13531084HCID 13531084, compound

Product 1

HCID 19609556HCID 19609556, compoundYield 68.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Hydrazine monohydrate (16 mL, 324 mmol) is added to a room temperature solution of methyl 3-[[3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanoate (3.5 g, 10.8 mMol) in methanol (110 mL). The reaction mixture is heated at reflux for 2 hours, then cooled, diluted with ethyl acetate and washed six times with water and once with brine. Drying the organic phase over magnesium sulfate and evaporation provides a crude solid which is chromatographed on a column of silica with methanol/chloroform (5/95) to afford 2.4 g (64%) of 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanoic acid hydrazide, mp 107.0°-110.0° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 2 hours
  3. temperaturecooled
  4. washwashed six times with water
  5. customDrying the organic phase
  6. customover magnesium sulfate and evaporation
  7. customprovides a crude solid which
  8. customis chromatographed on a column of silica with methanol/chloroform (5/95)

Sources & evidence

ORD record
ord-abe3f67bbbc24ea38d9e2c3ceced520c
Source dataset
uspto-grants-1992_04
Patent number
US05102897

Reaction notes

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