2,6-Dimethyl-8-ethyl-1-deazapurine → Hydrochloric Acid

HRID 1029603Notes

Reaction equation

HRID 1029603 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([CH2:11][CH3:12])[NH:10][C:5]2=[C:4]([CH3:13])[CH:3]=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:21]2[C:25]([C:26]3[C:31]([C:32]4[CH:37]=[CH:36][C:35]([CH2:38]Br)=[CH:34][CH:33]=4)=[CH:30][CH:29]=[C:28]([Cl:40])[CH:27]=3)=[N:24][N:23]=[N:22]2)C=CC=CC=1>>[CH3:1][C:2]1[N:7]=[C:6]2[N:8]([CH2:38][C:35]3[CH:34]=[CH:33][C:32]([C:31]4[CH:30]=[CH:29][C:28]([Cl:40])=[CH:27][C:26]=4[C:25]4[NH:21][N:22]=[N:23][N:24]=4)=[CH:37][CH:36]=3)[C:9]([CH2:11][CH3:12])=[N:10][C:5]2=[C:4]([CH3:13])[CH:3]=1.[ClH:40]

Participants

4

Reactant 2

HCID 98153742,6-Dimethyl-8-ethyl-1-deazapurineHCID 131717266HCID 131717266, compound

Product 2

HCID 313Hydrochloric AcidHCID 178437429HCID 178437429, compound

Procedure

The title compound was prepared from 5,7-dimethyl-2-ethylimidazo[4,5-b]pyridine and N-triphenylmethyl-5-(4'-bromomethyl-4-chlorobiphen-2-yl)tetrazole in a manner similar to Example 7, and was isolated as an HCl salt. 1H NMR (300 MHz, CD3OD) δ1.38 (t, 3H), 2.72 (s, 6H), 3.28 (q, 2H), 5.82 (s, 2H), 7.18 (d, 2H), 7,36 (d, 2H), 7.44 (s, 1H), 7.58 (d, 1H), 7.72 (dd, 1H), 7.76 (d, 1H); FAB mass spectrum, m/e 444 (M+H, calcd for C24H22N7Cl, 444).

Sources & evidence

ORD record
ord-41fa016124b340819916306559d7503b
Source dataset
uspto-grants-1992_04
Patent number
US05102880

Reaction notes

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