HCID 13543385, compound → HCID 15117289, compound

HRID 1029654Notes

Reaction equation

HRID 1029654 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][CH2:10][C@H:9]1[C:14]([O:16][CH2:17][CH3:18])=[O:15])C1C=CC=CC=1.[H][H]>CO.[OH-].[OH-].[Pd+2]>[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][C@H:9]1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

5

Reactant 2

HCID 13543385HCID 13543385, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15117289HCID 15117289, compoundYield 92.3%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A solution of ethyl (3S)-4-benzylmorpholine-3-carboxylate (6.50 g) in methanol (130 ml) was hydrogenated under atmospheric pressure of hydrogen over 20% palladium hydroxide on carbon (0.6 g) for 3 hours at ambient temperature. The catalyst was filtered off and the methanol was evaporated to give ethyl (3S)-morpholine-3-carboxylate (3.83 g) as a syrup.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe methanol was evaporated

Sources & evidence

ORD record
ord-ecccfb36f93d4ad6b0c54ce3efb6372f
Source dataset
uspto-grants-1992_04
Patent number
US05102877

Reaction notes

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