反应详情

To a solution of 1-[(3-fluoro-4-pyridinyl)propylamino]-1H-indol-5-ol (2.5 g) in 50 ml THF was added potassium carbonate (1.2 g), followed by methyl isocyanate (0.53 ml). After stirring at ambient temperature for three hours, the mixture was filtered, and the filtrate was concentrated to give a solid, 3.0 g, m.p. 165°-166° C. This material was eluted on a silica gel column with ethyl acetate/dichloromethane (1:1) via HPLC. The desired fractions were combined and concentrated to give a solid, 2.7 g, m.p. 177°-178° C.

1. filtrationthe mixture was filtered
2. concentrationthe filtrate was concentrated
3. customto give a solid, 3.0 g, m.p. 165°-166° C
4. washThis material was eluted on a silica gel column with ethyl acetate/dichloromethane (1:1) via HPLC
5. concentrationconcentrated
6. customto give a solid, 2.7 g, m.p. 177°-178° C.