反应详情

4.2 g of the 1,4-bis(benzyloxy)-2,3-epoxybutane thus obtained was dissolved in a mixture comprising 120 ml of tetrahydrofuran and 30 ml of water. Then 30 ml of an aqueous solution containing 6 ml of 60% perchloric acid was added dropwise thereto under ice-cooling and stirring. After stirring at the same temperature for additional 4 hours, the reaction mixture was poured into ice/water and extracted with ether. The extract was washed with water and dried. After distilling off the solvent, the obtained oily residue was purified by column chromatography (silica gel, hexane/ethyl acetate) to thereby give 2.7 g of 1,4-bis(benzyloxy)-2,3-butanediol as a colorless liquid.

1. additionwas added dropwise
2. temperatureunder ice-cooling
3. stirringAfter stirring at the same temperature for additional 4 hours
4. extractionextracted with ether
5. washThe extract was washed with water
6. customdried
7. distillationAfter distilling off the solvent
8. customthe obtained oily residue was purified by column chromatography (silica gel, hexane/ethyl acetate)