反应详情

温度

100 °C

229 g (1 mol) of 3,4-bistrifluoromethylaniline were diazotized in a solution of 350 g of concentrated sulphuric acid in 1.25 1 of water using 70 g of sodium nitrite in 140 ml of water. After the diazonium salt solution became nitrite-free, it was added dropwise to a solution warmed to 100° C. consisting of 550 ml of water, 210 g of sodium cyanide, 10 g of copper(I) cyanide, 500 g of sodium hydrogencarbonate and 9 g of nickel sulphate x 7 H2O. The product was isolated from the reaction mixture by steam distillation and subsequently distilled again. 152 g of product having a boiling point at 14 mbar of 85° C. and a melting point of 71° to 72° C. were obtained. This corresponds to a yield of 63% of theory.

1. additionwas added dropwise to a solution
2. customThe product was isolated from the reaction mixture by steam distillation
3. distillationsubsequently distilled again
4. customat 14 mbar of 85° C.
5. customa melting point of 71° to 72° C. were obtained