1H-1,2,4-Triazole → HCID 14837825, compound

HRID 1030100Notes

Reaction equation

HRID 1030100 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10](Cl)[C:9]2[C:4](=[C:5]([CH3:13])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:14]1[CH:18]=[N:17][CH:16]=[N:15]1.C(=O)(O)[O-].[Na+]>C(O)C.O>[N:14]1([C:10]2[C:9]3[C:4](=[C:5]([CH3:13])[CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([CH3:1])[CH:11]=2)[CH:18]=[N:17][CH:16]=[N:15]1

Participants

6

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 516892Sodium BicarbonateHCID 8095564-Chloro-2,8-dimethylquinoline

Product 1

HCID 14837825HCID 14837825, compoundYield 88.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

A mixture of 1.91 g of 2,8-dimethyl-4-chloro-quinoline and 1.38 g of 1,2,4-triazole is melt at 120° C. and stirred for 2 hours. The solidified melt is dissolved in a mixture of ethanol and water. The solution is poured into a solution of 0.84 g of sodium bicarbonate and 20 ml of water. The precipitated product is filtered. Thus 1.97 g of the desired compound are obtained, yield 88%, m.p.: 99°-100° C.

Workup

  1. customis melt at 120° C.
  2. filtrationThe precipitated product is filtered

Sources & evidence

ORD record
ord-55034389cfa84a9f8639427fabb7ec3c
Source dataset
uspto-grants-1992_04
Patent number
US05104884

Reaction notes

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